A P53-DEPENDENT RESPONSE LIMITS EPIDERMAL STEM CELL FUNCTIONALITY AND ORGANISMAL SIZE IN MICE WITH SHORT TELOMERES.

A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres.

Telomere maintenance is essential to ensure proper size and function of organs with a high turnover.In particular, a dwarf phenotype as well as phenotypes associated to premature loss of tissue regeneration, including the skin (hair loss, hair graying, decreased wound healing), are found in mice deficient for telomerase, the enzyme responsible for

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From Relativistic to Quantum Universe: Observation of a Spatially-Discontinuous Particle Dynamics beyond Relativity

We perform an experimental test where we directly observe light-induced electron transitions with a macroscopic spatial discontinuity.The effect is related to the fundamental indivisibility of macroscopic orbit-like quantum states reminiscent of so-called extended states in the integer quantum Hall system.The test has become realizable due to the d

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Current treatments for acute heart failure: focus on serelaxin

Robert G BennettVA Nebraska-Western Iowa Health Care System and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USAAbstract: Acute heart failure remains an enormous health concern worldwide, and is a major cause of death and hospitalization.In spite ORG NAT SEASAME SEEDS of this, the treatment strategies for acute

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How spatial variation in areal extent and configuration of labile vegetation states affect the riparian bird community in Arctic tundra.

The Arctic tundra is Jumper Display currently experiencing an unprecedented combination of climate change, change in grazing pressure by large herbivores and growing human activity.Thickets of tall shrubs represent a conspicuous vegetation state in northern and temperate ecosystems, where it serves important ecological functions, including habitat

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